| Identification | Back Directory | [Name]
Tenovin-6 | [CAS]
1011557-82-6 | [Synonyms]
CS-1015
Tenovin-6
Tenovin-6, >=98%
Tenovin 6 - Tnv 6
Tenovin-6 USP/EP/BP
TENOVIN 6; TENOVIN6
Tenovin-6, 98%, SIRT inhibitor and p53 activator
4-(tert-Butyl)-N-((4-(4-(dimethylamino)butanamido)phenyl)carbAmothioyl)benzamide
4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide
4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
4-TERT-BUTYL-N-(4-(5-(DIMETHYLAMINO)PENTANAMIDO)PHENYLCARBAMOTHIOYL)BENZAMIDE HYDROCHLORIDE
N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
Benzamide, N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin-6 | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C25H34N4O2S | [MDL Number]
MFCD28142830 | [MOL File]
1011557-82-6.mol | [Molecular Weight]
454.628 |
| Chemical Properties | Back Directory | [density ]
1.171±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20° C | [solubility ]
≥22.75 mg/mL in DMSO; insoluble in H2O; ≥2.62 mg/mL in EtOH with ultrasonic | [form ]
solid | [pka]
9.11±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Tenovin-6 Hydrochloride, is a small molecule activator of p53 transcriptional activity. It acts as a potent SIRT1 and SIRT2 inhibitor as well. | [Definition]
ChEBI: Tenovin-6 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide. It has a role as an antineoplastic agent, a Sir2 inhibitor and a p53 activator. It is a monocarboxylic acid amide, a member of thioureas and a tertiary amino compound. | [target]
SIRT1 | [storage]
Store at -20° C |
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