| Identification | Back Directory | [Name]
Termitomycamide E | [CAS]
1177258-62-6 | [Synonyms]
Termitomycamide E
(9Z,12Z)-N-[2-(4-hydroxyphenyl)ethyl]octadeca-9,12-dienamide
9,12-Octadecadienamide, N-[2-(4-hydroxyphenyl)ethyl]-, (9Z,12Z)- | [Molecular Formula]
C26H41NO2 | [MOL File]
1177258-62-6.mol | [Molecular Weight]
399.61 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson’s, Alzheimer’s, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites. Termitomycamide E is a fatty acid isolated from T. titanicus that at a dose of 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.1 | [References]
1. Choi, J.H., Maeda, K., Nagai, K., et al. Termitomycamides A to E, fatty acid amides isolated from the mushroom Termitomyces titanicus, suppress endoplasmic reticulum stress Org. Lett. 12(21),5012-5015(2010). |
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