| Identification | Back Directory | [Name]
PAz-PC | [CAS]
117746-89-1 | [Synonyms]
PazePC
16:0-09:0 (ALDO) PC
1-PALMITOYL-2-AZELAOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;PAZPC
1-PALMITOYL-2-(9'-OXO-NONANOYL)-SN-GLYCERO-3-PHOSPHOCHOLINE;16:0-09:0 (ALDO) PC | [Molecular Formula]
C33H64NO10P | [MOL File]
117746-89-1.mol | [Molecular Weight]
665.836 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
PazePC is an oxidatively modified phospholipid that modulates reactions between Bax (a pro-apoptotic protein) and mitochondrial membranes under intracellular oxidative stress, often resulting in cell death. PazePC is found in low density cholesterol (LDL). | [General Description]
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) structure contains an anionic carboxyl group at the end of the short, oxidized acyl chain. | [Biochem/physiol Actions]
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) is an oxidized lipid. PAzePC acts as an inter- H2O2 permeation promoter. It serves as a drug target for antipsychotic drugs and antimicrobial agents in cells under oxidative stress at inflammatory sites. PAzePC facilitates permeabilization of Bax associated-mitochondrial membranes under oxidative stress. |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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