| Identification | Back Directory | [Name]
HA 130 | [CAS]
1229652-21-4 | [Synonyms]
HA 130
HA 150
CS-1606
HA130 (HA-130)
HA130;HA-130;HA 130
HA130 (Autotaxin Inhibitor)
(Z)-3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenylboronic acid
B-[3-[[4-[[3-[(4-Fluorophenyl)Methyl]-2,4-dioxo-5-thiazolidinylidene]Methyl]phenoxy]Methyl]phenyl]boronic Acid
Boronic acid, B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]- | [Molecular Formula]
C24H19BFNO5S | [MDL Number]
MFCD20926343 | [MOL File]
1229652-21-4.mol | [Molecular Weight]
463.29 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF:10.0(Max Conc. mg/mL);21.58(Max Conc. mM)
DMSO:30.11(Max Conc. mg/mL);64.99(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.08(Max Conc. mM) | [form ]
Powder |
| Hazard Information | Back Directory | [Uses]
HA 150 is a selective boronic acid-based inhibitor of autotaxin. Studies show that adminstration of HA 150 in mice results in rapid decrease of the lipid mediator lysophosphatidic acid (LPA) in the circulation. These findings suggest that HA 150 may provide useful therapeutic strategy in treating disorders associated with vascular development, inflammation, fibrotic disease, and tumor progression. | [storage]
Store at -20°C |
|
|