| Identification | Back Directory | [Name]
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | [CAS]
124489-20-9 | [Synonyms]
N-OH-PHIP
N2-OH-PhIP
N-HYDROXY-PHIP
N-HYDROXY-2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
1-Methyl-2-(hydroxyamino)-6-phenyl-1H-imidazo[4,5-b]pyridine
2-(Hydroxyamino)-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine
N-(1-methyl-6-phenylimidazo[4,5-b]pyridin-2-yl)hydroxylamine
N-(1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridine-2-yl)hydroxyamine
2H-Imidazo[4,5-b]pyridin-2-one, 1,3-dihydro-1-methyl-6-phenyl-, oxime | [Molecular Formula]
C13H12N4O | [MDL Number]
MFCD00870431 | [MOL File]
124489-20-9.mol | [Molecular Weight]
240.26 |
| Hazard Information | Back Directory | [Uses]
2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine is a mutagenic metablite of PhIP. PhIP is the most abundant mutagenic heterocyclic amine in cooked foods. Studies have shown the activation of 2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in the formation of PhIP adducts and 5-OH-PhIP. | [Definition]
ChEBI: N-hydroxy-PhIP is an imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. It has a role as a carcinogenic agent, a mutagen, a genotoxin, a human xenobiotic metabolite, a mouse metabolite, a rat metabolite and a neurotoxin. It is an imidazopyridine and a hydroxylamine. It is functionally related to a PhIP. |
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