| Identification | Back Directory | [Name]
A 80b | [CAS]
135561-94-3 | [Synonyms]
A 80b
5H-Pyridazino[4,5-b]indole, 4-(3,5-dimethyl-1H-pyrazol-1-yl)-1-(2-methylhydrazinyl)- | [Molecular Formula]
C16H17N7 | [MOL File]
135561-94-3.mol | [Molecular Weight]
307.35 |
| Hazard Information | Back Directory | [Description]
A-80b is a synthesized pyridazino[4,5-b]indole derivate. A 80b shows potent and long-lasting antihypertensive activity and lowers blood pressure. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. A-80b exerts a hypotensive and antihypertensive effect, possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores. |
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CHEMICAL LAND21
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