| Identification | Back Directory | [Name]
Fidarestat | [CAS]
136087-85-9 | [Synonyms]
Aldos
Sk 860
CS-489
SNK-860
fidarestat
Fidarestat
(SNK-860
(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide
(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione
(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide
(2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
(2S,4S)-6-FLUORO-2'',5''-DIOXOSPIRO(3,4-DIHYDRO-2H-1-BENZOPYRAN-4,4''-IMIDAZOLIDINE)-2-CARBOXAMIDE
Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S,4S)-
Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 2,3-dihydro-2',5'-dioxo-6-fluoro-, (2S-cis)-
Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S-cis)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C12H10FN3O4 | [MDL Number]
MFCD00919183 | [MOL File]
136087-85-9.mol | [Molecular Weight]
279.22 |
| Chemical Properties | Back Directory | [density ]
1.61±0.1 g/cm3(Predicted) | [solubility ]
DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
8.46±0.40(Predicted) |
| Hazard Information | Back Directory | [Biological Activity]
Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes. | [in vitro]
Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats. | [in vivo]
Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. | [target]
IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10) |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0.htm |
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