| Identification | Back Directory | [Name]
HUMAN PAI-1 | [CAS]
140208-23-7 | [Synonyms]
PAIE
PLANH1
Serpine 1
HUMAN PAI-1
PAI-1, MUTANT
Serpin E1 PAI-1
PAI-1, MUTANT, HUMAN
Human SERPINE1 Protein, His Tag
HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-1
Recombinant Mouse Serpine1 Protein, His Tag
Recombinant Human SSERPINE1 Protein, His Tag
Plasminogen activator inhibitor 1 (PAI-1) human
PLASMINOGEN ACTIVATOR INHIBITOR-1, MUTANT, HUMAN
PLASMINOGEN ACTIVATOR INHIBITOR-1, MUTANT, HUMAN, RECOMBINANT
Plasminogen activator inhibitor, β-migrating endothelial cell-derived type
Plasminogen activator inhibitor 1 (PAI-1) human recombinant, expressed in E. coli, >=90% (SDS-PAGE) | [MDL Number]
MFCD01094930 |
| Hazard Information | Back Directory | [Uses]
Plasminogen activator inhibitor 1 (PAI-1) human has been used:
- as an inhibitor of pro-brain-derived neurotrophic factor (proBDNF) in radioimmunoprecipitation assay (RIPA) in peripheral blood and lymphocytes
- to block plasmin activation in mice infected with C. albicans hyphae
- to test its effect on neurite growth in neurons
| [General Description]
Plasminogen activator inhibitor 1 (PAI-1) or serine protease inhibitor E1 (SERPINE1) gene is mapped to human chromosome 7q22.1. PAI-1 is produced in hepatocytes, endothelial cells, smooth muscle cells, megakaryocytes, and adipocytes. | [Biochem/physiol Actions]
Plasminogen Activator Inhibitor 1 (PAI-1) protein belongs to the Serpin superfamily of serine protease inhibitors. It is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and therefore inhibits the fibrinolysis process. PAI is involved in extracellular matrix remodeling and has been implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis. PAI-1 is present in increased levels in various disease states such as a number of cancer forms, obesity and the metabolic syndrome. |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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Energy Chemical
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| Website: |
http://www.energy-chemical.com |
| Company Name: |
AntibodySystem
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027-65279366 18162686757 |
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www.antibodysystem.com |
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