| Identification | Back Directory | [Name]
Rutamycin | [CAS]
1404-59-7 | [Synonyms]
A-272
RR-32705
Rutamycin
RRNo-32705
oligomycin D
26-Demethyloligomycin A
RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A | [Molecular Formula]
C44H72O11 | [MDL Number]
MFCD32640222 | [MOL File]
1404-59-7.mol | [Molecular Weight]
777.042 |
| Chemical Properties | Back Directory | [Melting point ]
116-119° | [alpha ]
D20 -62° (c = 1.36 in CHCl3) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A lyophilisate |
| Hazard Information | Back Directory | [Description]
Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 μM. | [Uses]
Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities. | [Uses]
Oligomycin D is an inhibitor of mitochondrial F1F0-ATPase. | [storage]
Store at -20°C |
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