| Identification | Back Directory | [Name]
Heterophyllin B | [CAS]
145459-19-4 | [Synonyms]
Heterophylin B
Heterophyllin B
Prince Ginseng Cyclic Peptide B
Cyclo(glycylglycyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-phenylalanyl)
Cyclo(glycylglycyl-L-isoleucyl-L-prolyl-L-prolyl-L-prolyl-L-isole ucyl-L-phenylalanyl) | [EINECS(EC#)]
300-006-6 | [Molecular Formula]
C40H58N8O8 | [MDL Number]
MFCD22125018 | [MOL File]
145459-19-4.mol | [Molecular Weight]
778.94 |
| Chemical Properties | Back Directory | [Boiling point ]
1159.7±65.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in DMSO | [pka]
13.44±0.70(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystal, easily soluble in methanol, derived from Radix Radix. | [Uses]
Taizishencyclopeptide B has the functions of invigorating qi and blood, invigorating body fluid and invigorating the spleen and stomach. And it was used for content determination/identification/pharmacological experiments, etc. | [Biological Activity]
Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. It can be used in esophageal cancer research. | [in vitro]
Heterophyllin B (0-200 μM; 12-48 hours) reduces cell viability in the 75, 100 and 200 μM groups, has no effect on 5, 10, 25 and 50 μM groups.Heterophyllin B (0 -50 μM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells. < /p> Cell Viability Assay | Cell Line: | ECA-109 cells | | Concentration: | 5 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM and 200 μM | | Incubation Time: | 12, 24 and 48 hours | | Result: | Decrease cell viability at high concentrations. | Western Blot Analysis | Cell Line: | ECA-109 cells | | Concentration: | 0 μM, 10 μM, 25 μM, 50 μM | | Incubation Time: | 6 hours | | Result: | Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin. | |
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