| Identification | Back Directory | [Name]
BAR 501 impurity | [CAS]
1632118-70-7 | [Synonyms]
BAR 501 impurity
(3alpha,5beta,6beta,7alpha)-6-Ethylcholane-3,7,24-triol
(3R,5S,6S,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-[(2R)-5-hydroxypentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol | [Molecular Formula]
C26H46O3 | [MDL Number]
MFCD30747751 | [MOL File]
1632118-70-7.mol | [Molecular Weight]
406.64 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/mL; DMSO: 100μg/ml; Ethanol: 2 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 500μg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay.1
| [References]
1. Festa, C., Renga, B., D'Amore, C., et al. Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands J. Med. Chem. 57(20),8477-8495(2014). |
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