| Identification | Back Directory | [Name]
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol | [CAS]
17019-46-4 | [Synonyms]
Erythrofuranosyladenine
9-β-D-Erythrofuranosyladenine
(2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol | [Molecular Formula]
C9H11N5O3 | [MDL Number]
MFCD28016443 | [MOL File]
17019-46-4.mol | [Molecular Weight]
237.215 |
| Hazard Information | Back Directory | [Description]
Erythrofuranosyladenine, also known as 9-beta-D-Erythrofuranosyladenine and ETA, is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. The cytotoxicity of EFA to hematopoietic progenitors erythroid burst-forming units (BFU-Es) and granulocyte-macrophage colony-forming units (CFU-GMs) was at least 26- to 41-fold less than that of MTA. EFA selectively rescued MTAP+ MOLT-4 cells from L-alanosine toxicity at 25 microM with negligible toxicity even at 100 microM. EFA is an effective agent for salvaging MTAP+ cells from L-alanosine toxicity and is superior to MTA due to lower cytotoxicity. |
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