| Identification | Back Directory | [Name]
PB28dihydrochloride | [CAS]
172906-90-0 | [Synonyms]
PB-28
PB28 dihydrochloride >=98% (HPLC), solid
Piperazine,1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-
1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazinedihydrochloride | [Molecular Formula]
C24H38N2O | [MDL Number]
MFCD06798349 | [MOL File]
172906-90-0.mol | [Molecular Weight]
370.57 |
| Hazard Information | Back Directory | [Uses]
PB 28 is a selective σ2 receptor agonist. It is also an antitumor and cytotoxic agent. | [Definition]
ChEBI: PB28 is a member of the class of tetralins that is tetralin that is substituted by 3-(4-cyclohexylpiperazin-1-yl)propyl and methoxy groups at positions 1 and 5, respectively. It is a sigma 2 (sigma2) receptor agonist (Ki = 0.68 nM) and exhibits antineoplastic and anti SARS-CoV-2 activities. It has a role as an anticoronaviral agent, an antineoplastic agent, an apoptosis inducer and a sigma-2 receptor agonist. It is an aromatic ether, a member of piperazines and a member of tetralins. | [Biological Activity]
High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells. |
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Energy Chemical
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MedChemExpress
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www.medchemexpress.com |
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