| Identification | Back Directory | [Name]
L-778123 | [CAS]
183499-57-2 | [Synonyms]
123
L 778
L-778
L-778123 free base
L 778123 free base,L778123 free base
1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone
L-778123 FREE BASE; L-778123; L 778123; L778123; L-778,123; L 778,123; L778,123;
4-[5-[4-(3-Chlorophenyl)-3-oxopiperazin-1-ylmethyl]imidazol-1-ylmethyl]benzonitrile
4-((5-((4-(3-Chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile
4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]Benzonitrile
Benzonitrile, 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]- | [Molecular Formula]
C22H20ClN5O | [MDL Number]
MFCD00951568 | [MOL File]
183499-57-2.mol | [Molecular Weight]
405.88 |
| Chemical Properties | Back Directory | [Boiling point ]
698.9±55.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml,Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
7.07±0.20(Predicted) |
| Hazard Information | Back Directory | [Definition]
ChEBI: L-778,123 (free base) is a member of the class of imidazoles that is 1H-imidazole substituted by (4-cyanophenyl)methyl and [4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl groups at positions 1 and 5, respectively. It is a dual inhibitor of FPTase and GGPTase-I. It has a role as an EC 2.5.1.58 (protein farnesyltransferase) inhibitor, an EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor and an antineoplastic agent. It is a member of monochlorobenzenes, a piperazinone, a member of imidazoles, a tertiary amino compound and a nitrile. |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|