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19313-28-1

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19313-28-1 Structure

19313-28-1 Structure
IdentificationBack Directory
[Name]

15(R)-PROSTAGLANDIN E1
[CAS]

19313-28-1
[Synonyms]

PGE0
13,14-dihydro PGE1
Prostaglandin E0 >
AlprostadilImpurity5
13,14-Dihydroprostaglandinee1
13,14-DIHYDROPROSTAGLANDIN E1
Prostaglandin E1 Impurity 5 (PGE0)
90% (20% solution in ethyl acetate)
13,14-Dihydro-prostaglandin E1 (PGE0)
9-oxo-11α,15S-dihydroxy-prostan-1-oic acid
9-OXO-11ALPHA,15S-DIHYDROXY-PROSTAN-1-OIC ACID
(11R)-11α,15α-Dihydroxy-9-oxoprostan-1-oic acid
Prostan-1-oic acid,11,15-dihydroxy-9-oxo-, (11a,15S)-
Prostaglandin E0 >90% (20% solution in ethyl acetate)
Prostan-1-oic acid, 11,15-dihydroxy-9-oxo-, (11α,15S)-
7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoctyl]-5-oxocyclopentyl]heptanoic acid
[Molecular Formula]

C20H36O5
[MDL Number]

MFCD00135208
[MOL File]

19313-28-1.mol
[Molecular Weight]

356.5
Chemical PropertiesBack Directory
[storage temp. ]

Refrigerator, under inert atmosphere
[solubility ]

Ethyl Acetate, Methanol, Tetrahydrofuran
[form ]

Colorless to pale yellow oil
[Stability:]

Volatile
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319-H336
[Precautionary statements ]

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
Hazard InformationBack Directory
[Description]

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.
[Uses]

Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.
[Definition]

ChEBI: 13,14-Dihydro PGE1 is a prostanoid.
[storage]

Store at -20°C
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