| Identification | Back Directory | [Name]
PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE | [CAS]
207671-42-9 | [Synonyms]
LUTIDINIC ACID MONOHYDRATE
PYRIDINE-2,4-DICARBOXYLIC ACID HYDRATE
2,4-PYRIDINECARBOXYLIC ACID MONOHYDRATE
2,4-PYRIDINEDICARBOXYLIC ACID MONOHYDRATE
PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE
2,4-Pyridinedicarboxylicacid, hydrate (1:1)
2,4-Pyridinedicarboxylic acid Monohydrate 98% | [EINECS(EC#)]
629-130-1 | [Molecular Formula]
C7H7NO5 | [MDL Number]
MFCD00149413 | [MOL File]
207671-42-9.mol | [Molecular Weight]
185.13 |
| Chemical Properties | Back Directory | [Melting point ]
246-248 °C (dec.)(lit.) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 1.4 mg/ml; PBS (pH 7.2): 0.2 mg/ml | [form ]
A crystalline solid | [BRN ]
131631 |
| Hazard Information | Back Directory | [Description]
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters. | [storage]
Store at -20°C |
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