| Identification | Back Directory | [Name]
Propargyl-PEG8-NHS ester | [CAS]
2182601-74-5 | [Synonyms]
2182601-74-5
Propargyl-PEG8-NHS ester
Propargyl-PEG7-CH2CH2COONHS
4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C24H39NO12 | [MDL Number]
MFCD31536764 | [MOL File]
2182601-74-5.mol | [Molecular Weight]
533.57 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment. | [Biological Activity]
Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Cleavable | PEGs | Alkyl/ether | |
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