ChemicalBook--->CAS DataBase List--->24928-15-2

24928-15-2

24928-15-2 Structure

24928-15-2 Structure
IdentificationBack Directory
[Name]

PHORBOL 12,13-DIACETATE
[CAS]

24928-15-2
[Synonyms]

PDA
PHORBOL-DIACETATE
phorbol10,11-diacetate
phorbol11,12-diacetate
PHORBOL 12,13-DIACETATE
Phorbol 12,13-Diacetate >99%
PHORBOL 12,13-DIACETATE, 4BETA
l)-1,1,6,8-alpha-tetramethyl-,9,9a-diacetate,(+)
5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-alpha,16-beta,4,4a,7a-alpha,7b,
8,9,9a-decahydro-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethy
(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-5-oxo-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulene-4aβ,7bα,9β,9aα-tetrol 9,9a-diacetate
(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl diacetate
5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9,9a-bis(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-
[Molecular Formula]

C24H32O8
[MDL Number]

MFCD00036735
[MOL File]

24928-15-2.mol
[Molecular Weight]

448.51
Chemical PropertiesBack Directory
[Boiling point ]

477.23°C (rough estimate)
[density ]

1.1793 (rough estimate)
[refractive index ]

1.4480 (estimate)
[storage temp. ]

−20°C
[solubility ]

H2O: soluble
[form ]

powder
[color ]

white
[BRN ]

2317312
Safety DataBack Directory
[Hazard Codes ]

T+
[Risk Statements ]

26/27/28-36/37/38
[Safety Statements ]

26-27-36/37/39-45
[RIDADR ]

UN 2811 6.1/PG 3
[WGK Germany ]

3
[RTECS ]

GZ0651000
[F ]

8-10
[HazardClass ]

6.1(a)
[PackingGroup ]

II
[HS Code ]

2915290000
Hazard InformationBack Directory
[Uses]

Phorbol 12,13-diacetate may be used to stimulate protein kinase C (PKC) for phosphorylation of retinal proteins.
[General Description]

Phorbol ester with enhanced hydrophilicity.
[Biochem/physiol Actions]

Phorbol 12,13-diacetate (PDA) serves as a protein kinase C (PKC). It induces arrest in translocation in rod photoreceptors. PDA facilitates PKC in regulating airway contractility by inducing transient relaxation after a sustained contraction of the human isolated bronchus. PDA improves the synaptic transmission of nociceptive parabrachioamygdaloid (PBA) input onto neurons of the capsular central amygdaloid (CeAC) nucleus via activating PKC and extracellular-regulated kinase (ERK).
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