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301356-95-6

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301356-95-6 Structure

301356-95-6 Structure
IdentificationBack Directory
[Name]

CID5721353
[CAS]

301356-95-6
[Synonyms]

CID5721353
BCL6 inhibitor
CID-5721353;CID 5721353
CID5721353, BCL6 inhibitor
BCL6 inhibitor(CID5721353)
CID5721353 BDL6 inhribitor
79-6 (CID5721353， BCL6 inhibitor)
CID 5721353;CID-5721353;CID 5721353
2-(5-(5-bromo-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)succinic acid
Butanedioic acid, 2-[5-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinyl]-
[Molecular Formula]

C15H9BrN2O6S2
[MDL Number]

MFCD31729277
[MOL File]

301356-95-6.mol
[Molecular Weight]

457.28
Chemical PropertiesBack Directory
[density ]

2.06±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

3.02±0.23(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

CID-5721353 is an inhibitor of the transcriptional repressor B cell lymphoma 6 (Bcl-6; Ki = 147 μM). It is selective for Bcl-6 over Kaiso, hypermethylated in cancer 1 (HIC1), and promyelocytic leukemia zinc finger (PLZF) at 50 μM. CID-5721353 is cytotoxic against Bcl-6-dependent SU-DLH-6, SU-DLH-4, Farage, OCI-LY7, OCI-LY1, and OCI-LY10 diffuse large B cell lymphoma (DLBCL) cells (GI50s = 0.024-0.936 mM) but not Bcl-6-independent Toledo or OCI-LY4 DLBCL cells (GI50 = >15 mM for both). It increases expression of the Bcl-6 target genes ATR, TP53, CD69, p21, and CD44 in SU-DLH-6 and SU-DHL-4 cells when used at a concentration of 50 μM. CID-5721353 (50 mg/kg) reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models.
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