| Identification | Back Directory | [Name]
ANTIPAIN, DIHYDROCHLORIDE | [CAS]
37682-72-7 | [Synonyms]
ANTIPAIN
Antipain HCl
Antipain 2HCI
ANTIPAIN (2HCL)
ANTIPAIN HYDROCHLORIDE
Phe-Arg-Val-Arg-CHO.2HCl
ANTIPAIN, DIHYDROCHLORIDE
EZNA KIT ISOLATION FFPE RNA
ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL
n-(nα-carbonyl-arg-val-arg-al)-phe
TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS
N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE
N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL
ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE
antipain dihydrochloride from microbial source
N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride
Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem
N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE
Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem
[(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL
[(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL
[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL
(S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
Antipain dihydrochloride from microbial source protease inhibitor
[(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL
[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE
l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-(
[(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE
L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride
N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2)
L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride
L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2)
(9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride | [EINECS(EC#)]
609-466-5 | [Molecular Formula]
C27H46Cl2N10O6 | [MDL Number]
MFCD00135957 | [MOL File]
37682-72-7.mol | [Molecular Weight]
677.62 |
| Chemical Properties | Back Directory | [Melting point ]
209-217 °C | [Boiling point ]
652.92°C (rough estimate) | [density ]
1.2423 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
-20°C | [solubility ]
H2O: 50 mg/mL
| [form ]
White powder | [color ]
White | [Water Solubility ]
0.01M in water | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice. | [Uses]
Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM | [General Description]
Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation. | [Biochem/physiol Actions]
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. | [storage]
Store at -20°C | [References]
1) Umezawa?et al.?(1976),?Structures and activities of protease inhibitors of microbial origin; Method Enzymol.,?45?678
2) Gotoh?et al.?(2001),?Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors; J. Biosci. Bioeng.,?92?248
3) Hockensmith?et al. (2016), Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia; Microb. Pathog.,?100?37
4) Mat Amin?et al. (2004),?Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.; Trop. Biomed.,?21?57
5) Moriyyasu & Inoue (2008),?Use of protease inhibitor for detecting autophagy in plants; Methods Enzymol.,?451?557 |
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