Log in | Join Free | china | japan | germany
ChemicalBook--->CAS DataBase List--->405098-33-1

405098-33-1

Request For Quotation
405098-33-1 Structure

405098-33-1 Structure
IdentificationBack Directory
[Name]

N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE
[CAS]

405098-33-1
[Synonyms]

W-54011
CS-2062
C5a Receptor Antagonist, W-54011
N-{[4-(diMethylaMino)phenyl]Methyl}-7-Methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxaMide hydrochloride
N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE
[Molecular Formula]

C30H37ClN2O2
[MDL Number]

MFCD06659046
[MOL File]

405098-33-1.mol
[Molecular Weight]

493.08
Questions And AnswerBack Directory
[Uses]

W 54011 is a potent orally active non-peptide C5a receptor antagonist.
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 3 mg/mL
[form ]

White powder solid.
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Description]

W-54011 is an orally bioavailable, nonpeptide antagonist of complement component 5a receptor 1 (C5aR), also known as cluster of differentiation 88 (CD88). W-54011 inhibits 125I-rhC5a binding in neutrophils (Ki = 2.2 nM) and C5a-mediated intracellular Ca2+ mobilization (IC50 = 3.1 nM). W-54011 is selective and does not affect Ca2+ mobilization mediated by other G protein-coupled receptor (GPCR) ligands, N-Formyl-Met-Leu-Phe (fMLF; Item No. 21495), or IL-8 up to a concentration of 10 μM. It inhibits Ca2+ mobilization in neutrophils in humans, cynomolgus monkeys, and gerbils, but not in mice, rats, guinea pigs, rabbits, or dogs. At 10 nM, W-54011 also inhibits C5a-mediated migration and vessel formation of human microvascular endothelial cells (HMEC-1).
[storage]

Store at -20°C
405098-33-1 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Haoyuan Chemexpress Co., Ltd.  
Tel: 021-58950125
Website: http://www.chemexpress.com.cn
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Guangzhou QiYun Biotechnology Co., Ltd.  
Tel: 020-61288194 61288195
Website: www.gzqiyun.com
Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
Tel: 010-50973130 4009686088
Website: www.solarbio.com
Company Name: Nanjing KaiMubo Pharmaceutical Co., Ltd.   
Tel: 025-66162170
Website: www.chemicalbook.com/ShowSupplierProductsList19958/0.htm
Company Name: Musechem  
Tel: +1-800-259-7612
Website: www.musechem.com
Company Name: Shanghai Fred Chemical Co. Ltd.  
Tel: 021-54450827 021-54450828
Website: http://www.fwdchem.com.cn
Company Name: DC Chemicals  
Tel: 021-58447131 13564518121
Website: https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm
Company Name: Cckinase, Inc.  
Tel: +1 (732)236-3202
Website: www.cckinase.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: www.chemegen.com
Company Name: Shanghai hongqu biomedical technology co. LTD  
Tel: 88888888888
Website: www.chemicalbook.com/ShowSupplierProductsList873228/0.htm
Company Name: MedBioPharmaceutical Technology Inc  
Tel: 021-69568360 18916172912
Website: http://www.med-bio.cn/
Company Name: Wuhan Topule  
Tel: +86-02787215551 +86-19945035818
Website: http://www.topule.com/
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Website: http://www.weikeqi-biotech.com/
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840
Website: www.jm-bio.com/
Tags:405098-33-1 Related Product Information
93100-99-3 909725-64-0 61714-25-8 1345982-24-2 88519-57-7 909725-62-8