| Identification | Back Directory | [Name]
POLYPHYLLIN D | [CAS]
50773-41-6 | [Synonyms]
Paris I
Saponin Pa
Polyphyllin
Polyphyllin I
Polyphyllin C
Polyphillin D
Polyphyllin A
Polyphyllin Ⅰ
POLYPHYLLIN D
GLYCO-DIOSGENIN
Paris saponin Pa
Paridis saponin I
I,Chonglousaponin
POLYPHYLLIN D USP/EP/BP
Polyphyllin I(Chonglou Saponin I)
Chonglou Saponin I(Polyphyllin A)
Polyphyllin I, 98%, from Paris polyphylla Smith var.chinensis
Polyphyllin D / Diosgenyl 4-O-α-L-arabinofuranosyl-2-O-α-L-rhamnopyranosyl-β -D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1→4)-O-[6-deoxy-α-L-mannopyranosyl-(1→2)]- | [Molecular Formula]
C44H70O16 | [MOL File]
50773-41-6.mol | [Molecular Weight]
855.02 |
| Hazard Information | Back Directory | [Description]
Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity.1 It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells.2 Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.1 | [Uses]
Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers. |
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