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516-21-2

516-21-2 Structure

516-21-2 Structure
IdentificationBack Directory
[Name]

Cycloguanil
[CAS]

516-21-2
[Synonyms]

WR-5473
Chlorazin
Aids007020
Aids-007020
Cycloguanyl
Cycloguanil
Cycloguanil-d6
Cycloguanil HCl
CYCLOCHLOROGUANIDE
609-78-9 (Pamoate)
Chlorguanide triazine
Nsc3074(hydrochloride)
152-53-4 (Hydrochloride)
1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine
6,6-Dimethyl-5-(4-chlorophenyl)-5,6-dihydro-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-
[Molecular Formula]

C11H14ClN5
[MDL Number]

MFCD00838855
[MOL File]

516-21-2.mol
[Molecular Weight]

251.72
Chemical PropertiesBack Directory
[Melting point ]

146°
[Boiling point ]

397.13°C (rough estimate)
[density ]

1.2332 (rough estimate)
[refractive index ]

1.6110 (estimate)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Uses]

Antimalarial.
[Definition]

ChEBI: Cycloguanil is a triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antiinfective agent, an antiparasitic agent, an antimalarial, an antiprotozoal drug and an antifolate.
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