| Identification | Back Directory | [Name]
SCUTELLAREIN | [CAS]
529-53-3 | [Synonyms]
SCUTELLAREIN
Scutellartln
Scutillarein
isocarthamidin
6-HYDROXYAPIGENIN
SCUTELLAREIN WITH HPLC
SCUTELLAREIN, 98.0% BY HPLC
5,6,7,4'-TETRAHYDROXYFLAVONE
4',5,6,7-TETRAHYDROXYFLAVONE
Scutellarein, froM Scutellaria barbata
Scutellarein, 98%, from Scutellaria barbata
5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
5,6,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one
2-(4-Hydroxyphenyl)-5,6,7-trihydroxy-4H-1-benzopyran-4-one
5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-(4-hydroxyphenyl)- | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C15H10O6 | [MDL Number]
MFCD00017692 | [MOL File]
529-53-3.mol | [Molecular Weight]
286.24 |
| Chemical Properties | Back Directory | [Melting point ]
330°C | [Boiling point ]
642.9±55.0 °C(Predicted) | [density ]
1.654±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble1mg/mL, clear, greenish-yellow | [form ]
powder | [pka]
6.34±0.40(Predicted) | [color ]
yellow | [InChIKey]
JVXZRQGOGOXCEC-UHFFFAOYSA-N | [LogP]
2.540 (est) |
| Hazard Information | Back Directory | [Description]
Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities.1,2,3,4,5,6 It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml.2 Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively).3,4 It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.5 In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.6 | [Chemical Properties]
Yellow solid | [Uses]
Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue. | [Definition]
ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7. |
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