| Identification | Back Directory | [Name]
7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one | [CAS]
532-16-1 | [Synonyms]
7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one
2H-1-Benzopyran-2-one, 7-[(3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)oxy]-
(E,E)-7-((3,7,11-Trimethyl-2,6,10-dodecatrienyl)oxy)-2H-1-benzopyran-2-one | [Molecular Formula]
C24H30O3 | [MOL File]
532-16-1.mol | [Molecular Weight]
366.49 |
| Hazard Information | Back Directory | [Definition]
ChEBI:Umbelliprenin is a terpene lactone. | [Biological Activity]
Umbelliprenin is a prenylated coumarin that has been found in Ferula and has diverse biological activities.1,2 It inhibits 5-lipoxygenase (5-LO) in a cell-free assay (IC50 = 72.5 nM).1 Umbelliprenin is active against L. major promastigotes (IC50 = 13.3 μM) and lethal to A. albopictus fourth instar larvae (LC50 = 194.96 ppm). It induces cell cycle arrest at the G1 phase in, as well as inhibits the growth of (IC50 = 12.5 μM), M4Beu metastatic pigmented melanoma cells and reduces tumor volume in a mouse Lewis lung carcinoma model. It reduces tumor growth and the number of metastases in a 4T1 mouse allograft model.2 Umbelliprenin (0.01 mmol/kg) reduces carrageenan-induced paw edema in mice.1 | [storage]
-20°C | [References]
1.Shakeri, A., Iranshahy, M., and Iranshahi, M.Biological properties and molecular targets of umbelliprenin--a mini-reviewJ. Asian Nat. Prod. Res.16(8)884-889(2014)
2.Rashidi, M., Khalilnezhad, A., Amani, D., et al.Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c miceJ. Cell. Physiol.233(11)8908-8918(2018)
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