| Identification | Back Directory | [Name]
acetyl Methanesulfonate | [CAS]
5539-53-7 | [Synonyms]
NSC 158252
Busulfan Impurity 6
Busulfan Impurity 10
acetyl Methanesulfonate
Methanesulfonyl acetate
Acetic acid, anhydride with methanesulfonic acid | [Molecular Formula]
C3H6O4S | [MOL File]
5539-53-7.mol | [Molecular Weight]
138.14 |
| Chemical Properties | Back Directory | [Boiling point ]
56 °C(Press: 0.01 Torr) | [density ]
1.346±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Sparingly) | [form ]
Oil | [color ]
Yellow | [Stability:]
Extremely Moisture Sensitive |
| Hazard Information | Back Directory | [Uses]
Acetyl Methanesulfonate, is an impurity of Busulfan (B689900), an alkylating agent with antileukemic activity. Antineoplastic. | [Purification Methods]
The main impurity is methanesulfonic acid. Reflux it with redistilled acetyl chloride for 6-10hours, i.e. until no further HCl is absorbed in a trap, and exclude moisture. Distil off excess of AcCl and carefully distil it below 0.001mm with the bath temperature below 120o to give the anhydride as a pale yellow oil which solidifies below 0o. Below ~130o it gives the disulfonic anhydride, and above ~130o polymers are formed, and it is used for cleaving ethers [Preparation, IR, NMR: Karger & Mazur J Org Chem 36 528, 532 1971]. [Beilstein 2 H 166, 2 III 349.] |
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