| Identification | Back Directory | [Name]
CHLORMETHIAZOLE HYDROCHLORIDE | [CAS]
6001-74-7 | [Synonyms]
Somnevrin hydrochloride
CloMethiazole Hydrochloride
Clomethiazole hydrochloride salt
Chlormethiazole Hydrochloride >
4-methyl-5-(β-chloroethyl)thiazole hydrochloride
Inhibitor,Clomethiazole,Chlormethiazole hydrochloride,Chlormethiazole,inhibit
4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride | [Molecular Formula]
C6Cl2H9N1S1 | [MDL Number]
MFCD00673948 | [MOL File]
6001-74-7.mol | [Molecular Weight]
198.11 |
| Chemical Properties | Back Directory | [Melting point ]
130℃ | [storage temp. ]
Desiccate at RT | [solubility ]
H2O: >10 mg/mL, soluble
| [form ]
crystalline
| [color ]
off-white
| [Merck ]
14,2384 | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Chlormethiazole Hydrochloride was used in the study of effect of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system. | [Biochem/physiol Actions]
Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug. | [Clinical Use]
#N/A | [Drug interactions]
Potentially hazardous interactions with other drugs
Antipsychotics: enhanced sedative effects.
Antivirals: concentration possibly increased by
ritonavir.
Cimetidine: inhibits metabolism of clomethiazole. | [Metabolism]
Clomethiazole is extensively metabolised, probably by
first-pass metabolism in the liver with only small amounts
appearing unchanged in the urine. The rate of elimination
is decreased by about 30% in liver cirrhosis. |
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TCI AMERICA
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Sigma-Aldrich
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