| Identification | Back Directory | [Name]
RO 106-9920 | [CAS]
62645-28-7 | [Synonyms]
RO 106-9920
Ro 106-9920
DISCONTINUED
TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE
6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE
Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)- | [Molecular Formula]
C10H7N5OS | [MDL Number]
MFCD06660085 | [MOL File]
62645-28-7.mol | [Molecular Weight]
245.26 |
| Hazard Information | Back Directory | [Uses]
Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. | [Definition]
ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide. | [Biological Activity]
Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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