| Identification | Back Directory | [Name]
Mesaconine | [CAS]
6792-09-2 | [Synonyms]
Mesaconine
product/155130
Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, (1α,3α,6α,14α,15α,16β)-
(1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-1,6,16-Trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-3,8,13,14,15-pentol | [Molecular Formula]
C24H39NO9 | [MDL Number]
MFCD29917565 | [MOL File]
6792-09-2.mol | [Molecular Weight]
485.57 |
| Hazard Information | Back Directory | [Uses]
New use of neoaconitrile in the preparation of medicaments for preventing and/or treating myocardial fibrosis and chronic heart failure caused by myocardial fibrosis | [Biological Activity]
Mesaconinean, the active ingredient extracted from Aconitum carmichaelii Debx., has cardiovascular effects. | [Pharmacology]
1) Inhibit or reverse myocardial tissue fibrosis; 2) Improve abnormal cardiac remodeling; 3) Improve cardiac dysfunction; 4) Improve the survival rate of mice with chronic heart failure caused by myocardial fibrosis; 5) Fight against myocardial tissue inflammation; 6 ) Inhibition of cardiomyocyte apoptosis; 7) Myocardial enzyme activity in dead mice, and its mechanism of action is related to inhibiting myocardial tissue inflammation and fibrosis caused by adriamycin and resisting cardiomyocyte apoptosis. |
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