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681282-72-4

681282-72-4 Structure

681282-72-4 Structure
IdentificationBack Directory
[Name]

Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-diMethylethoxy)carbonyl]aMino]-3,5-dihydroxy-, (αS)-
[CAS]

681282-72-4
[Synonyms]

Saxagliptin Impurity 19
Boc-3,5-dihydroxy-1-adamantyl-L-glycine
(S)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dihydroxyadamantan-1-yl)acetic acid
(2S)-2-((tert-butoxycarbonyl)amino)-2-((3R,5S)-3,5-dihydroxyadamantan-1-yl)acetic acid
(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5S,7S)-3,5-dihydroxyadamantan-1-yl)acetic acid
(2S)-2-[(3R,5S)-3,5-dihydroxy-1-adamantyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-diMethylethoxy)carbonyl]aMino]-3,5-dihydroxy-, (αS)-
[Molecular Formula]

C17H27NO6
[MOL File]

681282-72-4.mol
[Molecular Weight]

341.4
Chemical PropertiesBack Directory
[Boiling point ]

534.7±35.0 °C(Predicted)
[density ]

1.406±0.06 g/cm3(Predicted)
[pka]

3.93±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Boc-3,5-dihydroxy-1-adamantyl-L-glycine is a reactant in the synthesis of Saxagliptin (S143500), a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
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