| Identification | Back Directory | [Name]
GMDP | [CAS]
70280-03-4 | [Synonyms]
GMDP
syl)muramoyl)-l-alanyl-
glucosaminylmuramyldipeptide
4-(2-ACETAMIDO-2-DEOXY-B-D- &
4-(2-acetamido-2-deoxy-B-D-*glucopyranosyl)-N-ace
d-glcnac-β-(1→4)-n-acetylmuramyl-l-ala-d-isoglutamine
D-GLCNAC-BETA-(1->4)-N-ACETYLMURAMYL-L-ALA-D-ISOGLUTAMINE
n-acetylglucosaminyl-n-acetylmuramyl-l-alanyl-d-isoglutamine
N-Acetyl-D-glucosaminyl-(b1,4)-N-acetylmuramyl-L-alanyl-D-io
n-acetyl-beta-glucosaminyl-n-acetylmuramyl-alanylisoglutamine
N-Acetyl-beta-D-Glucosaminyl-N-Acetylmuramyl-L-Alanyl-D-Isoglutamine
n-acetyl-beta-glucosaminyl-(1-4)-n-acetylmuramyl-l-alanyl-d-isoglutamine
N-ACETYL-D-GLUCOSAMINYL-(BETA1,4)-N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE
N-?Acetyl-?β-?D-?glucosaminyl-?N-?acetylmuramyl-?L-?alanyl-?D-?isoglutamine
4-(2-acetamido-2-deoxy-β-d-glucopyranosyl)-n-acetylmuramyl-l-ala-d-glu amide
d-alpha-glutamine,n-(n-acetyl-4-o-(2-(acetylamino)-2-deoxy-beta-d-glucopyrano
4-(2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSYL)-N-ACETYLMURAMYL-L-ALA-D-GLU AMIDE
D-α-Glutamine, N-[N-acetyl-4-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]muramoyl]-L-alanyl-
(4R)-4-((2S)-2-((2R)-2-(((3R,4R,5S,6R)-3-acetamido-5-(((2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)propanamido)propanamido)-5-amino-5-oxopentanoic acid | [Molecular Formula]
C27H45N5O16 | [MDL Number]
MFCD00132961 | [MOL File]
70280-03-4.mol | [Molecular Weight]
695.67 |
| Hazard Information | Back Directory | [Description]
N-acetyl-β-D-glucosaminyl-( 1→4)-N-acetylmuramyl-L-alanyl-D-isoglutamine
was launched in Russia for hospital-related infections, psoriasis, cervical precancerous
lesions and ophthalmic keratitis caused by herpes. It was found to be less
pyrogenic than MDP, the minimally active component of Freund's complete adjuvant.
While chemical synthesis is possible, a less laborious method (3 steps) involves the
enzymatic degradation of a bacterial peptidoglycan. GDMP is orally active with a low
toxicity that acts as an adjuvant to highly purified protein antigens to stimulate the
induction of CD8* T-cell response. It was also able to reduce the levels of TNF-α, IL-1α and hypoglycemia induced by LPS administration and to inhibit systemic
response to endotoxin. | [Originator]
Peptech (Australia) | [Uses]
N-?Acetyl-?β-?D-?glucosaminyl-?N-?acetylmuramyl-?L-?alanyl-?D-?isoglutamine acts as an immunnomodulator or immunostimulant in the treatment of various auto-immune diseases. | [Definition]
ChEBI: Glucosaminylmuramyl dipeptide is a dipeptide. | [Brand name]
Likopid |
|
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
|