| Identification | Back Directory | [Name]
Teneligliptin | [CAS]
760937-92-6 | [Synonyms]
Teliglietin
teneligliptin
Teneligptin WS
Teneligliptin (MP-513)
API (Teneligliptin free base)
3-[[(2S,4R)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine
3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine
Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-
[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone | [Molecular Formula]
C22H30N6OS | [MDL Number]
MFCD13195565 | [MOL File]
760937-92-6.mol | [Molecular Weight]
426.58 |
| Chemical Properties | Back Directory | [Melting point ]
>100°C (dec.) | [Boiling point ]
663.4±55.0 °C(Predicted) | [density ]
1.38 | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.70±0.10(Predicted) | [color ]
Off-White |
| Hazard Information | Back Directory | [Description]
Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM). | [Originator]
Mitsubishi Tanabe Pharma (Japan) | [Uses]
Teneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body. | [Definition]
ChEBI: Teneligliptin is an amino acid amide. | [Brand name]
Tenelia | [storage]
Store at -20°C |
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