| Identification | Back Directory | [Name]
KM 11060 | [CAS]
774549-97-2 | [Synonyms]
KM 11060
KM11060;KM-11060
CFTR-F508del Corrector, KM11060
7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE
7-CHLORO-4-[4-[4-CHLOROPHENYL)SULFONYL]-1-PIPERAZINYL]QUINOLINE
Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]- | [Molecular Formula]
C19H17Cl2N3O2S | [MDL Number]
MFCD01524977 | [MOL File]
774549-97-2.mol | [Molecular Weight]
422.33 |
| Hazard Information | Back Directory | [Uses]
KM 11060 is a small molecular corrector of F508del CFTR trafficking, which has potential application in cystic fibrosis therapeutics. | [Biological Activity]
Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity. | [storage]
Store at RT |
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