| Identification | Back Directory | [Name]
α-amine-ω-propionic acid diethylene glycol | [CAS]
791028-27-8 | [Synonyms]
NH2-PEG2-COOH
Amino-PEG2-acid
AMINE-PEG2-COOH
Amino-PEG2-COOH
Amino-PEG2-C2-acid
H2N-PEG2-CH2CH2COOH
Amino-PEG2-propionic acid
3-[2-(2-Aminoethoxy)ethoxy]-propanoic acid
Α-AMINE-Ω-PROPIONIC ACID DIETHYLENE GLYCOL
α-amine-ω-propionic acid diethylene glycol
Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-
alpha-aMine-oMega-propionic acid diethylene glycol
H2N-PEG2-CH2CH2COOH | [Molecular Formula]
C7H15NO4 | [MDL Number]
MFCD20926377 | [MOL File]
791028-27-8.mol | [Molecular Weight]
177.2 |
| Chemical Properties | Back Directory | [Boiling point ]
331.5±27.0 °C(Predicted) | [density ]
1.142±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
4.27±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Amino-PEG2-acid is a PEG reagent containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Biological Activity]
Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADClinker for the synthesis of antibody-drug conjugated Ck (ADC). It is also a PEG-based PROTAClinker that can be used for PROTAC synthesis. | [in vivo]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
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