| Identification | Back Directory | [Name]
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE | [CAS]
79183-19-0 | [Synonyms]
CS-572
MDK83190
APOPTOSIS ACTIVATOR 2
APOPTOSIS ACTIVATOR II
Apoptosis Activator 2, >=98%
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE
1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP
1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C15H9Cl2NO2 | [MDL Number]
MFCD00141556 | [MOL File]
79183-19-0.mol | [Molecular Weight]
306.14 |
| Chemical Properties | Back Directory | [Boiling point ]
470.6±55.0 °C(Predicted) | [density ]
1.494 | [Fp ]
238.4℃ | [storage temp. ]
Store at RT | [solubility ]
Soluble in DMSO | [form ]
Orange to red solid. | [pka]
-2.69±0.20(Predicted) | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. | [Definition]
ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles. | [Biological Activity]
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M). | [storage]
Store at -20°C | [References]
[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22. |
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