| Identification | Back Directory | [Name]
D609 | [CAS]
83373-60-8 | [Synonyms]
D609
D609 ,98%
D-609 POTASSIUM
D609 POTASSIUM SALT
D609 potassium salt,98%
Tricyclodecan-9-yl xanthate
Tricyclodecan-9-yl xanthogenate
tricyclodecane-9-yl-xanthogenate
TRICYCLODECAN-9-YL XANTHOGENATE K
Tricyclodecan-9-yl xanthate potassium salt
CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METH
TRICYCLODECAN-9-YL XANTHOGENATE POTASSIUM SALT
O-TRICYCLO(5.2.1.02,6)DEC-9-YL*DITHIOCAR BONATE POTA
O-TRICYCLO[5.2.1.0(2,6)]DEC-9-YL DITHIOCARBONATE POTASSIUM SALT
potassium O-(octahydro-4,7-methano-1H-inden-5-yl) dithiocarbonate
O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) CARBONOPOTASSIUM DITHIOATE
CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) ESTER POTASSIUM
Dithiocarbonic acid O-[(octahydro-4,7-methano-1H-inden)-5-yl]S-potassium salt
Carbonodithioic acid O-(octahydro-4,7-methano-1H-inden-5-yl) ester potassium salt | [EINECS(EC#)]
280-379-9 | [Molecular Formula]
C11H15KOS2 | [MDL Number]
MFCD00171401 | [MOL File]
83373-60-8.mol | [Molecular Weight]
266.46 |
| Chemical Properties | Back Directory | [Appearance]
white to off-white solid | [storage temp. ]
0-6°C | [solubility ]
H2O: 300 mg/mL
| [form ]
solid
| [color ]
off-white
| [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white solid | [Biological Activity]
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo . | [Description]
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells. | [Uses]
D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice. | [Biochem/physiol Actions]
D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids. | [storage]
Desiccate at -20°C | [References]
1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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