| Identification | Back Directory | [Name]
CID 16020046 | [CAS]
834903-43-4 | [Synonyms]
CS-1189
C390-0219
CID 16020046
CID16020046 (CID 16020046)
CID16020046;CID 16020046;CID 16020046
4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid
4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid
Benzoic acid, 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]- | [Molecular Formula]
C25H19N3O4 | [MDL Number]
MFCD06196075 | [MOL File]
834903-43-4.mol | [Molecular Weight]
425.44 |
| Chemical Properties | Back Directory | [Boiling point ]
748.1±60.0 °C(Predicted) | [density ]
1.425±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble1mg/mL, clear (warmed) | [form ]
powder | [pka]
4.27±0.10(Predicted) | [color ]
white to beige |
| Questions And Answer | Back Directory | [Uses]
CID 16020046 is a selective GPR55 antagonist. It Inhibits LPI-induced Ca2+ signaling, ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. It displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. It decreases LPI-induced GPR55 internalization. |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
CID16020046 is a potent and a selective GPR55 antagonist that inhibits GPR55-mediated ERK1/2 phosphorylation. CID16020046 inhibits LPI-induced Ca2+ signaling in HEK-GPR55 cells. | [storage]
Store at -20°C |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|