| Identification | Back Directory | [Name]
TG100801 | [CAS]
867331-82-6 | [Synonyms]
TG100801
TG100801;TG-100801
4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-amino)benzo[e][1,2,4]triazin-7-y
4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-amino)benzo[e][1,2,4]triazin-7-yl)p
4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenyl benzoate
4-Chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]phenol 1-benzoate
Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-, 1-benzoate | [Molecular Formula]
C33H30ClN5O3 | [MDL Number]
MFCD16038901 | [MOL File]
867331-82-6.mol | [Molecular Weight]
580.08 |
| Chemical Properties | Back Directory | [Boiling point ]
747.9±70.0 °C(Predicted) | [density ]
1.310 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
9.59±0.20(Predicted) |
| Hazard Information | Back Directory | [Biological Activity]
tg100801 is a multi-kinases inhibitor. it is a pro-drug version of tg100572. [1]tg100572 inhibits several growth factor receptors in addition to src family kinases. tg100801 significantly inhibited laser-induced cnv in mice, and suppressed fluorescein leakage from the vasculature and retinal thickening measured by optical coherence tomography in a rat model or retinal vein occlusion. tg100801 may play as a new topically applied treatment approach for ocular neovascularization and retinal edema. the highest concentration of tg100801 was found at the front of the rat eye (conjunctiva and cornea). [1] | [target]
VEGFR1 | [storage]
Store at -20°C | [References]
1. doukas j, mahesh s, umeda n et al. topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. j cell physiol. 2008 jul;216(1):29-37. |
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SPIRO PHARMA
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| Tel: |
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www.spiropharma.com.cn |
| Company Name: |
Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Henan Alfachem Co.,Ltd.
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0371-0371-55051623 18137891487 |
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www.chemicalbook.com/supplier/14555231/ |
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