| Identification | Back Directory | [Name]
L 2-401 | [CAS]
883050-24-6 | [Synonyms]
CS-563
L 2-401
CCG 50014
CCG50014;CCG 50014
CCG-50014 >=98% (HPLC)
4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione
4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C16H13FN2O2S | [MDL Number]
MFCD00113783 | [MOL File]
883050-24-6.mol | [Molecular Weight]
316.35 |
| Chemical Properties | Back Directory | [density ]
1.398±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα0, while blocking GTPase activity and Gα0-dependent translocation of RGS4 to the membrane. |
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