| Identification | Back Directory | [Name]
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate | [CAS]
89937-77-9 | [Synonyms]
NSC 132887
Methyl 2-hydroxypyridine-...
4-Methoxycarbonyl-2-pyridone
methyl 2-hydroxyisonicotinate
methyl 2-oxo-1H-pyridine-4-carboxylate
Methyl 2-hydroxypyridine-4-carboxylate
1,2-dihydro-2-oxopyridine-4-carboxylate
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
Methyl 2-oxo-1,2-dihydropyridine-4-carboxylate
Methyl 2-oxo-1,2-dihydro-4-pyridinecarboxylate
Methyl1,2-dihydro-2-oxopyridine-4-carboxylate98%
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate 98%
4-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester
4-Pyridinecarboxylicacid,1,2-dihydro-2-oxo-,methylester(9CI)
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate ISO 9001：2015 REACH
Methyl 2-hydroxypyridine-4-carboxylate, 1,2-Dihydro-4-(methoxycarbonyl)-2-oxopyridine | [Molecular Formula]
C7H7NO3 | [MDL Number]
MFCD09258780 | [MOL File]
89937-77-9.mol | [Molecular Weight]
153.135 |
| Chemical Properties | Back Directory | [Melting point ]
211-212 °C | [Boiling point ]
342.4±42.0 °C(Predicted) | [density ]
1.263±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
11.02±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is an ester derivative, mainly used as a pharmaceutical intermediate. | [Synthesis]
The synthesis method of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is as follows: Dissolve 10 g (0.066 mol) of m-nitrobenzaldehyde and 11 g (0.067 mol) of ethyl chloroacetate in 60 ml of benzene, and add 1 ml of piperidine. 1 ml of glacial acetic acid, heated in a water bath, and the water generated in the reaction was continuously removed with a Dean-start water separator. After refluxing for 3h, the benzene was evaporated, 20ml of ether was added to the residue, frozen, crystallized, suction filtered, and dried to give 16.2g of methyl 2-hydroxypyridine-4-carboxylate, yield 82%, mp 92 -96°C. |
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