| Identification | Back Directory | [Name]
EC 1.1.1.42 | [CAS]
9028-48-2 | [Synonyms]
IDH
IDH1
ICDH
MGC55806
MGC171441
MGC174090
EC 1.1.1.42
EC 1.1.1.42 TYPE I
EC 1.1.1.42 TYPE IV
:THREO-DS-ISOCITRATE
isocitric dehydrogenase
IsoCltrate dehydrogenase
ISOCITRATE DEHYDROGENASE
Oxalosuccinic decarboxylase
TPN-isocitrate dehydrogenase
ISOCITRIC DEHYDROGENASE (NADP)
TPN-linked isocitrate dehydrogenase
Isocitrate Dehydrogenase Cytoplasmic
Recombinant Isocitrate Dehydrogenase
TPN-specific isocitrate dehydrogenase
ISOCITRIC DEHYDROGENASE (NADP) TYPE I
ISOCITRIC DEHYDROGENASE (NADP) TYPE IV
TPN-dependent isocitrate dehydrogenase
NADP-specific isocitric dehydyrogenase
Recombinant Human IDH1 Protein, His Tag
Isocitrate Dehydrogenase 1 (NADP+) huMan
NADPH-dependent isocitrate dehydrogenase
THREO-DS-ISOCITRATE: NADP+ OXIDOREDUCTASE
isocitrate dehydrogenase from porcine heart
Native Porcine Isocitric Dehydrogenase (NADP)
Recombinant Human IDH1 C-his8 Protein, His Tag
isocitric dehydrogenase type I crude*from porcine
isocitric dehydrogenase (nadp) from porcine heart
ICDH, threo-Ds-Isocitrate: NADP+ oxidoreductase
Isocitrate Dehydrogenase preparation porcine heart
ISOCITRIC DEHYDROGENASE TYPE IV FROM*POR CINE HEART
ISOCITRIC DEHYDROGENASE HIGHLY PURIFIED FROM PORCIN
ISOCITRIC DEHYDROGENASE TYPE I CRUDE*FRO M PORCINE H
ISOCITRAT DEHYDROGENASE FROM PORCINE HEA RT, 3-8 U/MG
ISOCITRATE DEHYDROGENASE FROM PORCINE HE ART, ~10 U/MG
Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant
Isocitrate Dehydrogenase (NADP+) from Bacteria, Recombinant
Isocitrate dehydrogenase from Bacillus subtilis, Recombinant
THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING]
THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING] TYPE I
THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING] TYPE IV
rICDH (NAD), threo-Ds-Isocitrate: NAD oxidoreductase (decarboxylating)
rICDH (NADP), threo-Ds-Isocitrate: NAD oxidoreductase (decarboxylating)
Dehydrogenase, isocitrate (nicotinamide adenine dinucleotide phosphate)
Isocitric Dehydrogenase (NADP), Bacillus subtilis, recombinant from E. coli
Isocitrate dehydrogenase (NAD+) recombinant from Yeast, 50% glycerol solution
Isocitric Dehydrogenase (NADP) from porcine heart,threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH
Isocitric Dehydrogenase (NADP) from porcine heart Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein | [EINECS(EC#)]
232-835-3 | [Molecular Formula]
NULL | [MDL Number]
MFCD00131420 |
| Hazard Information | Back Directory | [Uses]
Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer . | [General Description]
Isocitrate dehydrogenase 1 (IDH1) gene is located on human chromosome 2q33. IDH1 is present in the cytoplasm and peroxisomes. It is expressed at high levels in the mammalian liver. IDH1 consists of a C-terminal tripeptide peroxisome, that targets the signal one sequence. | [Biochem/physiol Actions]
Isocitrate dehydrogenase 1 (IDH1) help in the oxidative carboxylation of isocitrate to α-ketoglutarate, that results in the formation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). It participates in lipid metabolism and glucose sensing. Suppressing IDH1 in pancreatic islets affects the insulin secretion, induced by glucose and leads to increase in lactate production. |
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