| Identification | Back Directory | [Name]
BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- | [CAS]
918430-49-6 | [Synonyms]
3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]ben
3,5-dichloro-N-((1-((2,2-diMethyltetrahydro-2H-pyran-4-yl)Methyl)-4-fluoropiperidin-4-yl)Methyl)benzaMide
3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]Benzamide
BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-
BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- | [Molecular Formula]
C21H29Cl2FN2O2 | [MDL Number]
MFCD11977740 | [MOL File]
918430-49-6.mol | [Molecular Weight]
431.37 |
| Chemical Properties | Back Directory | [Boiling point ]
510.1±50.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO (10 mg/ml) | [form ]
solid | [pka]
13.65±0.46(Predicted) | [color ]
Tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
TTA-P2 (918430-49-6) is a potent (IC50 = 100 nM), specific, and reversible antagonist of T-type calcium channels with no activity at high voltage calcium channels.1,2 Highly potent in two animal models of pain in vivo.3 | [References]
Shipe et al. (2008), Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist; J. Med. Chem., 51 3692
Dreyfus et al. (2010), Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window; J. Neurosci., 30 99
Choe et al. (2011), TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent; Mol. Pharmacol., 80 900 |
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| Company Name: |
Acesys Pharmatech
|
| Tel: |
18860950986 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15849/0.htm |
| Company Name: |
A.J Chemicals
|
| Tel: |
91-9810153283 |
| Website: |
www.ajchemicals.com |
| Company Name: |
AstaTech, Inc
|
| Tel: |
(215) 785 3197 |
| Website: |
www.astatechinc.com |
| Company Name: |
ARENA CHEMICAL
|
| Tel: |
33 979 998 163 |
| Website: |
www.arenachemical.com |
|