| Identification | Back Directory | [Name]
KAZUSAMYCIN A FROM STREPTOMYCES SP. | [CAS]
92090-94-3 | [Synonyms]
CL 1957B
PD-114721
Aids058215
Aids-058215
kazusamycin
kazusamycina
antibiotic81-484
antibioticcl1957b
94664-05-8 (Deleted)
KAZUSAMYCIN A FROM STREPTOMYCES SP.
2,10,12,16,18-Nonadecapentaenoic acid, kazusamycin a
KazusaMycin, HydroxyleptoMycin B, Hydroxyelactocin, CL 1957B, PD 114721
19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-2,10,12,16,18-nonadecapentenoic acid
2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-, (2E,10E,12E,16Z,18E)-
2,10,12,16,18-Nonadecapentaenoic acid, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-, (2E,5S,6R,7S,9S,10E,12E,15R,16Z,18E)- | [Molecular Formula]
C33H48O7 | [MDL Number]
MFCD03265635 | [MOL File]
92090-94-3.mol | [Molecular Weight]
556.73 |
| Hazard Information | Back Directory | [Uses]
Kazusamycin A is a minor member of the leptomycin complex isolated from some Streptomyces species. It is an hydroxylated analogue of leptomycin B, a nuclear export inhibitor. Kazusamycin A exhibits potent antitumour activity both in vitro and in vivo against P388 and L1210 cell lines, and also shows strong antibacterial and antifungal activity. | [Uses]
Kazusamycin A is a potent antibiotic shown to induce G2 cell cycle arrest and delay M phase. |
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