| Identification | Back Directory | [Name]
Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate | [CAS]
928659-17-0 | [Synonyms]
Triazavirin
Triazavirin (Riamilovir)
Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate
Sodium 7-(methylthio)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-6-ide dihydrate
1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate | [EINECS(EC#)]
690-013-3 | [Molecular Formula]
C5H7N6NaO4S | [MOL File]
928659-17-0.mol | [Molecular Weight]
270.2 |
| Hazard Information | Back Directory | [Biological Activity]
Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid, which inhibits the synthesis of viral RNA and DNA and the replication of genomic fragments. It is active against influenza and many other viruses, and acts as an effective protective agent during influenza transmission. | [in vitro]
The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain < i> Sofiin ) by accumulation in the SKEV cell culture. | [in vivo]
The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed. | [target]
Nucleoside analogue; Influenza virus |
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