102036-28-2
102036-28-2 结构式
基本信息
原苏木素A对照品
原苏木素A标准品
protosappanin A
PROTOSAPPANIN A (PTA)
3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one
6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-113573 | 原苏木素A Protosappanin A | 102036-28-2 | 1mg | 1850元 |
| 2024/04/30 | HY-113573 | 原苏木素A Protosappanin A | 102036-28-2 | 5mg | 5500元 |
| 2024/04/30 | HY-113573 | 原苏木素A Protosappanin A | 102036-28-2 | 10mg | 8800元 |
常见问题列表
|
JAK2
|
STAT3
|
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia.
Western Blot Analysis
| Cell Line: | Murine BV2 microglial cell line. |
| Concentration: | 12.5, 25, 50 μM. |
| Incubation Time: | 24 hours. |
| Result: |
Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells.
Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells. Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells. |