112228-65-6
中文名称
112228-65-6
英文名称
B 220
CAS
112228-65-6
分子式
C20H22N4
分子量
318.42
MOL 文件
112228-65-6.mol
更新日期
2023/03/20 15:41:17
112228-65-6 结构式
基本信息
中文别名
化合物B220化合物 T10445
英文别名
B 220Rat Anti Mouse B220 (CD45R)
6H-Indolo[2,3-b]quinoxaline-6-ethanamine, N,N,2,3-tetramethyl-
物理化学性质
熔点134-136 °C
沸点518.8±50.0 °C(Predicted)
密度1.18±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)7.75±0.28(Predicted)
常见问题列表
生物活性
B220 是一种能抑制 HSV-1，HSV-2 和人巨细胞病毒 (CMV) 生长的抗病毒剂。靶点
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HSV-1
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HSV-2
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体外研究
B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV). B220 inhibits neutrophil release of reactive oxygen species, as well as intracellular generation of reactive oxygen species. The inhibition is not achieved through direct oxygen radical scavenger activity of B220, and B220 has no immediate effects on the activity of the assembled oxidase. The neutrophil capability to phagocytose fluorescein-labeled opsonized yeast cells is reduced by B220. Cells preincubated with B220 (10 µg/mL) and then stimulated with the formylated peptide fMLP mobilize fewer C3 receptors on their surface than the control cells.