116229-36-8
116229-36-8 结构式
基本信息
Bactenecin/Bactenecin, bovine
L-Arginine,L-arginyl-L-leucyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-valyl-L-valyl-L-isoleucyl-L-arginyl-L-valyl-L-cysteinyl-,cyclic (3®
L-Arginine, L-arginyl-L-leucyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-valyl-L-valyl-L-isoleucyl-L-arginyl-L-valyl-L-cysteinyl-, cyclic (3→11)-disulfide
(2R)-2-[[(4S,7R,10R,13R,16S,28S)-28-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-13,22-di(butan-2-yl)-10,25-bis[3-(diaminomethylideneamino)propyl]-6,9,12,15,18,21,24,27-octaoxo-7,16,19-tri(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26-octazacyclononacosane-4-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
物理化学性质
常见问题列表
牛抗菌肽是一种从牛嗜中性粒细胞中分离出来的有效的含12个氨基酸的环状抗菌肽。它可抑制细菌和酵母菌(bacteria 和 yeast)的生长，并能杀死真菌红毛癣菌(fungus Trichophyton rubrum)。它还可增加膜的通透性，抑制假苹果芽孢杆菌(B. pseudomallei)的生长和生物膜的形成。
Bacteria; Yeast; Fungus
Bactenecin is synthesized by solid-phase peptide synthesis and renatured to a fully disulfide bonded form. Bactenecin inhibits the growth of
Escherichia coli
and
Staphylococcus aureus
at the same concentration reported for the peptide purified from bovine neutrophils. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus
Trichophyton rubrum
.
Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells.
Bactenecin exhibits stronger binding to LPS and induces perturbation of the inner membrane of live cells. Interaction of Bactenecin with model membranes results in changes in membrane fluidity and permeability, leading to leakage of dye across the membrane.