1191385-19-9

中文名称 [N/A]

英文名称 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)

CAS 1191385-19-9

分子式 C26H21Cl3N8

分子量 551.87

MOL 文件 1191385-19-9.mol

更新日期 2024/05/28 11:53:41

1191385-19-9 结构式

基本信息物理化学性质安全数据图谱信息 B-Raf 抑制剂 1 二盐酸盐价格(试剂级) 常见问题列表

基本信息

中文别名

B-RAF 抑制剂 1 二盐酸盐
化合物B-RAF INHIBITOR 1 DIHYDROCHLORIDE
N5-(3-(9H-嘌呤-6-基)吡啶-2-基)-N1-(4-氯苯基)-6-甲基异喹啉-1,5-二胺二盐酸盐

英文别名

MFCD18782676
5-isoquinolinediamine
B-Raf inhibitor 1 2HCl
Raf inhibitor 1 dihydrochloride
B-Raf inhibitor 1 dihydrochloride
n1-(4-chlorophenyl)-6-methyl-n5-[3-(9h-purin-6-yl)-2-pyridinyl]-
N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-1,5-ISOQUINOLINEDIAMINE 2HCL
N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridyl]isoquinoline-1,5-diamine dihydroc
N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine dihydrochloride
N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride

所属类别

生物化工：激动剂抑制剂

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

形态粉末

安全数据

海关编码2933998090

图谱信息

B-Raf 抑制剂 1 二盐酸盐(1191385-19-9)核磁图(¹HNMR)

B-Raf 抑制剂 1 二盐酸盐价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	S6660	[N/A] B-Raf inhibitor 1 (Compound 13) dihydrochloride	1191385-19-9	5mg	1285.95元
2024/04/30	S6660	[N/A] B-Raf inhibitor 1 (Compound 13) dihydrochloride	1191385-19-9	25mg	5627.35元

常见问题列表

生物活性

B-Raf inhibitor 1 (Compound 13)是一种IIA型Raf抑制剂，与DFG-out构象结合，对B-Raf(WT)，B-Raf(V600E)和C-Raf的ki分别为1 nM，1 nM和0.3 nM。

靶点

Target	Value
C-Raf (Cell-free assay)	0.3 nM(Ki)
B-Raf(WT) (Cell-free assay)	1 nM(Ki)
B-Raf(V600E) (Cell-free assay)	1 nM(Ki)

体外研究

B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC ₅₀ s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.