119687-33-1
119687-33-1 结构式
基本信息
中文别名
伊加地平 英文别名
Iganidipine3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2,2-dimethyl-3-[4-(2-propen-1-yl)-1-piperazinyl]propyl] 5-methyl ester
常见问题列表
生物活性
Iganidipine 是一种钙离子通道拮抗剂。靶点
Ca 2+
体内研究
Iganidipine (0.03% solution) significantly increases optic nerve head (ONH) tissue blood velocity (NB ONH ) by 8 to 10% in treated eyes after a single administration (p<0.05) or by 18 to 35% after 7-, 14-, or 21-day twicedaily administration in rabbits (p<0.05). In monkeys, 0.03% and 0.1% Iganidipine significantly increases NB ONH in treated eyes by 20 and 41% after 7-day (p<0.05) twice-daily administration, respectively.