123931-04-4
中文名称
R(+)-3-氨基-1-羟基-2-吡咯烷酮
英文名称
(R)-(+)-HA-966
CAS
123931-04-4
分子式
C4H8N2O2
分子量
116.12
MOL 文件
123931-04-4.mol
123931-04-4 结构式
基本信息
中文别名
(3R)-3-氨基-1-羟基-2-吡咯烷酮R(+)-3-氨基-1-羟基-2-吡咯烷酮
英文别名
Zinc03791818(R)-(+)-HA-966
R(+)-HA-966 R(+)-3-AMINO-1-HYDROX
(3R)-3-Amino-1-hydroxy-2-pyrrolidinone
R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE
(R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE
2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)-
(R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate
所属类别
有机原料：杂环化合物物理化学性质
熔点166℃
沸点258.6±50.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
储存条件Desiccate at RT
溶解度H2O: soluble
溶解度可溶于水中
酸度系数(pKa)7.19±0.20(Predicted)
形态solid
颜色white
旋光性 (optical activity)[α]22/D +103°, c = 1 in H2O(lit.)
水溶解性溶于水至100mM
常见问题列表
生物活性
(R)-(+)-HA-966 ((+)-HA-966) 是 N-甲基-D-天冬氨酸 (NMDA) 受体复合物的甘氨酸位点的部分激动剂/拮抗剂。(R)-(+)-HA-966 通过苯丙胺选择性阻断中脑边缘多巴胺系统的活化。(R)-(+)-HA-966 可透过血脑屏障，有用于神经性和急性疼痛的潜力。靶点
glycine site of the NMDA receptor
体内研究
(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.).
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g).
| Animal Model: | Sprague-Dawley rats (11 to 12 weeks old) |
| Dosage: | 10 mg/kg |
| Administration: | IV |
| Result: | Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA. |